The Boruto Two Blue Vortex series focuses on character growth for Boruto post-timeskip, leaving fan-favorite character Orochimaru noticeably absent. Fans speculate on his potential return and significance in the ongoing storyline, given his past relevance as a recurring antagonist in the Naruto series. Orochimaru's cursed marks bear similarities to the Karma seals in the Boruto series, leading to theories that he might play a key role in resolving issues related to them. In Chapter 7 of Boruto Two Blue Vortex, Mitsuki begins questioning reality, sparking speculation about seeking counsel from Orochimaru.

With chapter 8 scheduled for March 20, 2024, fans eagerly anticipate Orochimaru's potential resurgence in the main plot after his absence in the current narrative.