Anime characters like Sai from Naruto are common protagonists, such as Shiina, Mashiro, and Violet Evergarden. These characters, like Sai, struggle with social skills due to their backgrounds. Oreki from Hyouka and Rei Kiriyama from March Comes in Like a Lion are introverted characters similar to Sai. Decim from Death Parade and Fushi from To Your Eternity lack communication skills like Sai. Rei Ayanami from Neon Genesis Evangelion is emotionless, like Sai, while Misaki from Another is isolated like Sai.

Lucy from Elfen Lied and Ram from Re: ZERO ~Starting Life in Another World are blunt and struggle with social interactions, resembling Sai. These characters share similarities in their personalities and struggles with social skills like Sai from Naruto.